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THE MONTANA BOARD OF MEDICAL EXAMINERS HAS FAILED MEDICAL SCIENCE AND ENDANGERED PUBLIC HEALTH
Despite this scientific certainty, medical boards and law enforcement often ignore it. Dr. Ibsen highlights the statistical reality of human variation: there is a 100% chance that 5% of the population will fall two standard deviations from the “average dose.”
This means a significant number of patients will genetically require much higher or lower doses than what guidelines might suggest. This willful disregard for established genetic science means current regulatory guidelines may be systematically forcing physicians to either undermedicate or overmedicate a significant portion of the population. This rejection of basic science creates an impossible situation for doctors, forcing them into a legal minefield.
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The Ignored Science: Your Genes Can Determine Your Need for Pain Medicine
The current regulatory environment often treats pain medication dosages with a one-size-fits-all approach, but established science directly contradicts this. Dr. Ibsen points to Cytochrome P450 (CYP450) tests, which analyze how an individual’s unique genetic makeup influences how they process, or metabolize, drugs. This genetic science, established over 20 years ago, demonstrates that different people require vastly different doses to achieve the same effect.
According to Tom Lynch, PharmD, and Amy Price, MD, in the Publication American Family Physician, an article written August 1, 2007, called The Effect of Cytochrome P450 Metabolism on Drug Response, Interactions, and Adverse Effects clearly pointed out;
“..Cytochrome P450 enzymes are essential for the metabolism of many medications. Although this class has more than 50 enzymes, six of them metabolize 90 percent of drugs, with the two most significant enzymes being CYP3A4 and CYP2D6. Genetic variability (polymorphism) in these enzymes may influence a patient’s response to commonly prescribed drug classes, including beta blockers and antidepressants….”
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