Examining Bias in Opioid Effectiveness: A Call for Retraction

from youarewithinthenorms.com

NORMAN J CLEMENT RPH., DDS, NORMAN L. CLEMENT PHARM-TECH, MALACHI F. MACKANDAL PHARMD, BELINDA BROWN-PARKER, IN THE SPIRIT OF JOSEPH SOLVO ESQ., INC., SPIRIT OF REV. IN THE SPIRIT OF WALTER R. CLEMENT BS., MS, MBA. HARVEY JENKINS, MD, PH.D., IN THE SPIRIT OF C.T. VIVIAN, JELANI ZIMBABWE CLEMENT, BS., M.B.A., IN THE SPIRIT OF THE HON. PATRICE LUMUMBA, IN THE SPIRIT OF ERLIN CLEMENT SR., EVELYN J. CLEMENT, IN THE SPIRIT OF WALTER F. WRENN III., MD., JULIE KILLINGSWORTH, RENEE BLARE, RPH, DR. TERENCE SASAKI, MD LESLY POMPY MD., CHRISTOPHER RUSSO, MD., NANCY SEEFELDT, IN THE SPIRIT OF WILLIE GUINYARD BS., JOSEPH WEBSTER MD., MBA, BEVERLY C. PRINCE MD., FACS., NEIL ARNAND, MD., IN THE SPIRIT OF RICHARD KAUL, MD., IN THE SPIRIT OF LEROY BAYLOR, JAY K. JOSHI MD., MBA, AISHA GARDNER, ADRIENNE EDMUNDSON, ESTER HYATT PH.D., WALTER L. SMITH BS., IN THE SPIRIT OF BRAHM FISHER ESQ., MICHELE ALEXANDER MD., CUDJOE WILDING BS, MARTIN NJOKU, BS., RPH., IN THE SPIRIT OF DEBRA LYNN SHEPHERD, BERES E. MUSCHETT, STRATEGIC ADVISORS

A Candidate Study for Retraction Watch From University of Sydney, Australia

Re https://scitechdaily.com/study-challenges-long-held…/

A senior man in a suit with glasses and a mustache, posing against a colorful sunset background. — Richard A. Lawhern, PhD

“..the flaws in averages used in medical treatment, highlighting the GIGO Law and genetic polymorphism’s impact on patient care..”

retraction on grounds of scientific idiocy and bias.

For the Academic Dean at the University of Sydney, Australia, and for the Chairman of your Academic Senate:

I write to suggest that a study conducted at the University of Sydney (link above) should be a near-term candidate for retraction on grounds of scientific idiocy and bias. I offer the following published papers as evidence for this nomination.

Infographic discussing the flaws in averages used in medical treatment, highlighting the GIGO Law and genetic polymorphism's impact on patient care. — Meta-analysis of a literature that is deeply influenced by bias and misinformation — which the literature on opioid safety and effectiveness is — can only produce nonsense.

A major weakness of the paper you have allowed to be published is that it ignores the GIGO law: Garbage In / Garbage Out. Meta-analysis of a literature that is deeply influenced by bias and misinformation — which the literature on opioid safety and effectiveness is — can only produce nonsense. That’s what this paper is.

A scientist in a lab coat working on a computer with a 3D DNA strand overlay and data graphs in the background. — This weakness, by itself, is fatal to the paper’s conclusions and, indeed, to over 90% of all published drug trials that fail to address variable metabolism. Any doctor who completes medical school will be aware of these realities.

When Garbage In becomes Garbage Out: Erasing the Cellular Memory of Pain

A FATAL WEAKNESS

A contributing weakness of the paper is its failure to mention the influence of genetic polymorphisms in liver enzymes, which affect the metabolism of almost 90% of clinically significant medications. This weakness, by itself, is fatal to the paper’s conclusions and, indeed, to over 90% of all published drug trials that fail to address variable metabolism. Any doctor who completes medical school will be aware of these realities.

VERDICT

A chart comparing the efficacy of opioids for pain relief, categorized into 'Modest / Short-term Relief' and 'Ineffective / No Better than Placebo', detailing specific conditions where opioids may provide moderate relief versus those where they are ineffective. — By your support of this garbage, you have made yourself an accessory to healthcare fraud and hundreds of negligent homicides

Be aware that this letter will be posted to social media venues that serve registered readerships of over two million healthcare professionals. You have messed up royally. If you hope to remain employed anywhere in academia, then you must fix the mess you made!

WILFUL SCIENTIFIC NEGLIGENCE

An expressive abstract painting of a person with their hands on their face, conveying strong emotions, with a dark and blue color palette. — PAIN IS REAL

By your support of this garbage, you have made yourself an accessory to healthcare fraud and hundreds of negligent homicides among patients denied safe and effective pain care on totally specious grounds.

Good Afternoon.